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KMID : 0361020000430050523
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 5 p.523 ~ p.527
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The Expression Pattern and the Prognostic Value of p53, p21, and Bax Proteins in Oral Squamous Cell Cancer
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Kim Sang-Hyun
Hwang Dong-Jo
Kim Jeong-Soo
Moon Jun-Hwan
No Ho-Sang
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Abstract
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Background and Objectives : The wild-type p53 protein activates different tumor
suppressor genes, leading to the G1 arrest following DNA damage. P21 and bax play a
pivotal role in the regulation of apoptosis. The authors wanted to find out the
relationship among p53, p21 and bax and the correlation between the staining results
and clinicopathologic factors. We also assessed their influence on survival in the oral
cavity cancer.
Materials and Methods : Paraffin embedded tissue sections were made from squamous
cell carcinoma of oral cavity from 46 patients. Tissue sections were
immunohistochemically stained for the expression of p53, p21 and bax. Results were
then compared with the size of primary tumor, lymph node metastasis and
histopathologic differentiation. The probability of survival was calculated by the
Kaplan-Meier method.
Results : Immunoreactivity of the p53 and p21 were detected dominantly in the nuclei at
various levels, and immunoreativity of bax was detected in the cytoplasm. The positive
rates of p53, p21, and bax were 54.4%, 58.7%, 26.1%, respectively. The positive rate of
p53 and the negative rate of bax expression were significantly increased with T-stage
but were not affected by N-stage and histopathologic differentiation. P21 had no
correlation with the T-stage, N-stage nor with pathologic differentiation. In the
multivariate analysis, neither the single oncoprotein nor the combinations of p53, p21,
bax had influence on survival statistically.
Conclusion : The bax protein and mutant p53 protein can be a biological marker for
primary tumor progression.
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KEYWORD
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Squamous cell carcinoma, Protein p53, p21/WAF1, Bax, Prognosis
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